Medications for withdrawal depend on the substance, but there are some common tools doctors use to make detox safer and more tolerable. For opioid withdrawal, meds like buprenorphine or methadone can ease symptoms and cravings, while clonidine helps with anxiety, sweating, and agitation. For alcohol, benzodiazepines such as diazepam, lorazepam, or chlordiazepoxide are standard in supervised detox, and later medications like naltrexone, acamprosate, or disulfiram can support ongoing recovery and reduce relapse risk. For other substances, doctors often use targeted meds to manage specific symptoms like nausea, insomnia, or anxiety rather than one single “withdrawal pill,” which is why medical supervision is strongly recommended.